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Image Search Results
Journal: Journal of Clinical Laboratory Analysis
Article Title: Laboratory and clinical evaluation of a microarray for the detection of ATP7B mutations in Wilson disease in China
doi: 10.1002/jcla.24735
Figure Lengend Snippet: Schematic representation of the 24 ATP7B loci and the arrangement of probes in the WD microarray.
Article Snippet: Probes were then spotted on the surface of the aldehyde group–based
Techniques: Microarray
Journal: Journal of Clinical Laboratory Analysis
Article Title: Laboratory and clinical evaluation of a microarray for the detection of ATP7B mutations in Wilson disease in China
doi: 10.1002/jcla.24735
Figure Lengend Snippet: List of ATP7B mutations selected for microarray detection.
Article Snippet: Probes were then spotted on the surface of the aldehyde group–based
Techniques: Microarray, Mutagenesis
Journal: Journal of Clinical Laboratory Analysis
Article Title: Laboratory and clinical evaluation of a microarray for the detection of ATP7B mutations in Wilson disease in China
doi: 10.1002/jcla.24735
Figure Lengend Snippet: Determination of cut‐off value for the 24 loci of ATP7B mutation by the microarray detection.
Article Snippet: Probes were then spotted on the surface of the aldehyde group–based
Techniques: Mutagenesis, Microarray
Journal: Journal of Clinical Laboratory Analysis
Article Title: Laboratory and clinical evaluation of a microarray for the detection of ATP7B mutations in Wilson disease in China
doi: 10.1002/jcla.24735
Figure Lengend Snippet: Representative result of multiplex asymmetric PCR and microarray detection. (A) Twelve bands of PCR products covering all detection sites are distributed in three tubes. The length of the bands and the target fragments in the three tubes are as follows: Tube 1, 287 bp (p.Y741C, p.D765G, p.R778L/Q), 250 bp (p.N1270S, p.T1286I), 172 bp (p.L692P), 137 bp (p.I1148T, p.E1173K); tube 2, 248 bp (p.R919G, p.T935M, p.G943D, p.G948C), 212 bp (p.G869R, p.A874V, p.T888P), 166 bp (p.S975Y, p.G1000R), 130 bp (p.V1106I); and tube 3, 260 bp (p.D196E, p.G250R), 226 bp (p.C490X), 196 bp (c.1708‐5 T>G, p.I592F), and 84 bp (p.I1230T). (B) A representative genotyping result of a clinical sample by microarray detection.
Article Snippet: Probes were then spotted on the surface of the aldehyde group–based
Techniques: Multiplex Assay, Microarray
Journal: Journal of Clinical Laboratory Analysis
Article Title: Laboratory and clinical evaluation of a microarray for the detection of ATP7B mutations in Wilson disease in China
doi: 10.1002/jcla.24735
Figure Lengend Snippet: Results of microarray detection of ATP7B mutation in 106 suspected WD cases and comparison with that by sequencing.
Article Snippet: Probes were then spotted on the surface of the aldehyde group–based
Techniques: Microarray, Mutagenesis, Sequencing
Journal: Journal of Clinical Laboratory Analysis
Article Title: Laboratory and clinical evaluation of a microarray for the detection of ATP7B mutations in Wilson disease in China
doi: 10.1002/jcla.24735
Figure Lengend Snippet: Schematic representation of the prevalence of individual ATP7B mutations in Chinese WD patients as detected by the microarray method. p.R778L (50.94%), p.A874V (17.92%), p.P992L (11.32%), p.V1106I (11.32%), and p.I1148T (6.60%) were the most common mutations. ATP7B p.P992L was identified by sequencing.
Article Snippet: Probes were then spotted on the surface of the aldehyde group–based
Techniques: Microarray, Sequencing
Journal: International Journal of Molecular Sciences
Article Title: Effects and Mechanism of Particulate Matter on Tendon Healing Based on Integrated Analysis of DNA Methylation and RNA Sequencing Data in a Rat Model
doi: 10.3390/ijms23158170
Figure Lengend Snippet: ( A ) Kyoto Encyclopedia of Genes and Genome (KEGG) pathways associated with the significantly upregulated and downregulated differentially expressed genes (DEGs) between particulate matter (PM)-exposed and control (non-PM) rats ( p < 0.05). ( B ) Canonical pathways with significant Z-scores (>2) identified using ingenuity pathway analysis. Heatmaps showing the DEGs in the ( C ) cAMP response element-binding protein (CREB) and ( D ) cAMP signaling pathways. ( E ) Schematic diagram showing the methods and criteria for gene analysis. ( F ) Venn diagram showing the combined DNA methylation and transcriptome data. The red circle indicates 67 genes exhibiting hypomethylated/upregulated expression. ( G ) The top five KEGG pathways associated with the hypomethylated/upregulated genes.
Article Snippet: A
Techniques: Control, Binding Assay, Protein-Protein interactions, DNA Methylation Assay, Expressing